By Sydney Bronski, Chloe Jones, Sierra Hinsdale, Olivia Romboletti

Faculty Mentor: Dr. Parrish Waters

Abstract

This study investigates the influence of exercise on social behavior and associated neurochemical markers in mice using the three-chamber test. Mice will be divided into groups with varying access to running wheels to assess how different levels of physical activity affect sociability and social preference. Behavioral outcomes will be paired with biochemical analyses measuring brain-derived neurotrophic factor (BDNF), c-Fos expression, and biochemical relationships with neurological factors. The goal is to evaluate whether increased exercise enhances social interaction and neural plasticity while reducing stress-related neurochemical responses. Findings from this research may provide insight into potential therapeutic strategies for neurodevelopmental and psychiatric disorders characterized by social deficits.